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Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial
Bruce E. Sands, Peter M. Irving, Timothy Hoops, James Izanec, Long-Long Gao, Christopher Gasink, Andrew Greenspan, Matthieu Allez, Silvio Danese, Stephen B. Hanauer, Vipul Jairath, Tanja Kuehbacher, James D. Lewis, Edward V. Loftus, Emese Mihály, Remo Panaccione, Ellen Scherl, О. Б. Щукина, William J. Sandborn, Anita Afzali, Lilia Aitova, Xavier Aldeguer i Mante, I Altorjay, Federico Argüelles‐Arias, Alessandro Armuzzi, Monika Augustyn, Mauro Bafutto, Jésus Barrio, Jakob Begun, Clint Behrend, Geert Bezemer, Guillaume Bonnaud, Marija Branković, Ik Jang Byung, Xavier Calvet, Karen A. Chachu, Júlio Maria Fonseca Chebli, Jae Hee Cheon, Halina Cichoż‐Lach, Larry Clark, Fraser Cummings, Kunal Dalal, Nanne K.H. de Boer, Maria de Lourdes Abreu Ferrari, Étienne Désilets, Predrag Dugalić, George Duvall, Olga Fedorishina, Rafał Filip, Cristina Flores, Ronald Fogel, James Fon, Michael Frankel, Keith Friedenberg, Walter Fries, Vassileva Galina, Piotr Gietka, Rishi Goel, Peter Hasselblatt, Hans Herfarth, László Herszényi, Pieter Hindryckx, Frank Hoentjen, Carmen Horjus Talabur Horje, Satish Iduru, Robert J. Isfort, Michael Jones, Dilara Kalimullina, Jeffry Katz, Manreet Kaur, Sunil K Khurana, Joo Sung Kim, Young‐Ho Kim, D Kleczkowski, Slavko Knezevic, Aaron Knoll, Louis Y Korman, Iskren Kotzev, Andrey Kulyapin, Kang‐Moon Lee, Desirée Leemreis, Jarosław Leszczyszyn, Jimmy K. Limdi, Jack J. Lissauer, Ewa Małecka‐Panas, John K. Marshall, Lukáš Milan, Giovanni Monteleone, Aleksandar Nagorni, Danuta Owczarek, Nichole Palekar, Young Soo Park, Sang Hyoung Park, Rogério Serafim Parra, Árpád V. Patai, Kamal Patel, Bhaktasharan Patel, Anatoly Pershko, Elina Petrova, Guillaume Pineton de Chambrun, Charles Randall, S. Riestra Menéndez, Timothy E. Ritter, Montserrat Rivero, Xavier Roblin, Rodolfo Rocca, Jacek Romatowski, Grażyna Rydzewska, Simone Saibeni, Bruce Salzberg, H Sarles, John B. Saunders, Edoardo Savarino, Zuzana Šerclová, Jonathan H. Siegel, Najm Soofi, Miles Sparrow, David Stokesberry, Daniel R. Suiter, Petar Svorcan, Tkachev Av, Nikolay Tsonev, Tünde Kristóf, Jan Ulbrych, Tomáš Vaňásek, Márta Varga, Séverine Vermeire, Raquel Vicente Lidón, Michael L Weiss, Emma Wesley, Nathaniel S. Winstead, Katarzyna Wójcik‐Pszczoła, Joanna Wypych, Cyrla Zaltman, Zdena Zadorova
Bibliographic record
VenueThe Lancet · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversity of CalgaryUniversity HospitalWestern University
FundersSeres TherapeuticsJanssen Scientific AffairsCrohn's and Colitis FoundationGilead SciencesGlaxoSmithKlinePfizerGenentechCelgeneAstraZenecaEli Lilly and Company
KeywordsMedicineUstekinumabAdalimumabClinical endpointCrohn's diseaseInternal medicineClinical trialPopulationRandomized controlled trialIntention-to-treat analysisAdverse effectRandomizationMaintenance therapyDiseaseChemotherapy
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.046
Threshold uncertainty score0.604
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.041
GPT teacher head0.299
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations297
Published2022
Admission routes1
Has abstractno