Giant circulating malignant cells spotted in feathered edge of blood film
Bibliographic record
Abstract
A 20-year-old male presented with a 4-week history of dry cough, night sweats, weight loss, and fever.Blood tests showed normocytic anemia (hemoglobin 71 g/L) and severe thrombocytopenia (platelets 17 × 10 9 /L).His blood film demonstrated leukoerythroblastosis, occa-F I G U R E 1 Large nonhematopoietic cells observed in the feathered edge of blood film (panel A), bone marrow aspirate (panel B), and bone marrow biopsy (panel C).The cells were CD43, pankeratin, weak CD30, and Sallike protein 4 (SALL4) (panels D-G).The final diagnosis was nonseminomatous germ cell tumor, not further classified.This was further supported by the presence of two isochromosome 12p, identified on karyotype and metaphase Fluorescence In Situ Hybridization (FISH) with the translocation-Ets-leukemia virus-6 (ETV6, 12p13.2) probe (panels H-I).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".