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Record W4282958950 · doi:10.1056/nejmc2204552

Troponin I after Cardiac Surgery and 30-Day Mortality

2022· letter· en· W4282958950 on OpenAlexaff

Bibliographic record

VenueNew England Journal of Medicine · 2022
Typeletter
Languageen
FieldMedicine
TopicCardiac, Anesthesia and Surgical Outcomes
Canadian institutionsMcMaster University
Fundersnot available
KeywordsMedicineCardiologyTroponinInternal medicineSurgeryMyocardial infarction

Abstract

fetched live from OpenAlex

Devereaux et al. corroborate the independent negative prognostic effect of increased levels of cardiac troponin I after cardiac surgery,1 reinforcing the notion derived from a meta-analysis of earlier studies2 that the predictive thresholds of 5670 ng per liter after coronary-artery bypass grafting (CABG) and aortic-valve replacement or repair and of 12,981 ng per liter after other cardiac surgery are much higher than the cut-off points endorsed in guidelines3 and provide sufficient prognostic information for identifying those patients with levels below these thresholds for whom there is a low likelihood of a complicated course. Although the authors were unable to differentiate ischemic myocardial damage from procedural injury, it is well recognized that levels of cardiac troponin I increase almost universally after cardiac surgery, and the magnitude of this increase varies depending on the surgical procedure performed and the anesthesia and cardioplegia used.1,4 We believe that their data beg the question of what is now the truly abnormal value of cardiac troponin I after cardiac surgery, because they have moved the threshold bar to particularly high values, thereby suggesting that caution has to be paid as to the clinical judgment used when integrating the variable elevated cardiac troponin I levels into the complex puzzle of other known powerful independent predictors of worse postoperative outcome.1

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.029
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.011
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.029
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0110.005
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.269
Teacher spread0.247 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2022
Admission routes1
Has abstractyes

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