Pregnancy Outcomes in Multifetal Gestation Who Underwent In-Vitro Fertilization (IVF) as Compared to Spontaneous Conceptions [A332]
Bibliographic record
Abstract
INTRODUCTION: This study’s aim is to compare pregnancy outcomes in multifetal gestations that were conceived spontaneously compared to in vitro fertilization (IVF). Few population-based studies have addressed this topic. METHODS: This is a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database. Our study cohort included 90,552 multifetal gestations conceived spontaneously and 3,219 IVF conceptions, from 2008-2014, inclusively. Multivariate logistic regression analyses were performed comparing maternal and neonatal outcomes, while adjusting for confounding variables. Subject was conducted using ICD-9 codes 651.X and 76.1 for multifetal gestation and ICD-9 code 23.85 for IVF. Each pregnancy was included once. RESULTS: IVF multifetal gestations had increased risk of pregnancy induced hypertension (adjusted odds ratio [aOR]:1.31, 95% CI, 1.20–1.43), gestational hypertension (aOR: 1.21, 95% CI, 1.04–1.41), preeclampsia (aOR: 1.31, 95% CI, 1.19–1.45), gestational diabetes (aOR: 1.26, 95% CI, 1.13–1.41) and placenta previa (aOR: 1.7, 95% CI, 1.32–2.19). IVF delivery outcomes were more likely complicated by cesarean section (aOR: 1.21, 95% CI, 1.10–1.33), preterm premature rupture of membranes (aOR: 1.33, 95% CI, 1.16–1.52), chorioamnionitis (aOR: 1.71, 95% CI, 1.37–2.14), postpartum hemorrhage (aOR: 1.44, 95% CI, 1.26–1.63) and transfusions (aOR: 1.48, 95% CI, 1.26–1.74). IVF neonatal outcomes were more likely complicated by small for gestational age (aOR: 1.26, 95% CI, 1.12–1.41) and congenital anomalies (aOR: 1.82, 95% CI, 1.29–2.57). IVF was not found to increase risks of eclampsia, preterm delivery, operative vaginal delivery, hysterectomy, or intrauterine fetal demise. CONCLUSION: Women with IVF multifetal pregnancies were more likely to have complications, with risks increased 20% to 70%. The role of infertility versus the need for IVF and the type of IVF protocol used should be further evaluated.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".