MétaCan
Menu
Back to cohort

Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study

2022· article· en· W4283261057 on OpenAlexaff
Yan Sun, Tianye Jia, Edward D. Barker, Di Chen, Zuo Zhang, Jiayuan Xu, Suhua Chang, Guangdong Zhou, Yun Liu, Nicole Tay, Qiang Luo, Xiao Chang, Tobias Banaschewski, Arun L.W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean‐Luc Martinot, Marie‐Laure Paillère Martinot, Éric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Lin Lü, Jie Shi, Günter Schumann, Sylvane Desrivières

Bibliographic record

VenueBiological Psychiatry · 2022
Typearticle
Languageen
FieldMedicine
TopicAttention Deficit Hyperactivity Disorder
Canadian institutionsUniversité de MontréalCentre Hospitalier Universitaire Sainte-Justine
FundersMedical Research FoundationNational Institute on Drug AbuseNational Key Research and Development Program of ChinaHorizon 2020Medical Research CouncilHigher Education Discipline Innovation ProjectUniversité Paris-SudShireFédération pour la Recherche sur le CerveauScience and Technology Commission of Shanghai MunicipalityFondation pour la Recherche MédicaleNational Natural Science Foundation of ChinaInstitut National de la Santé et de la Recherche MédicaleAgence Nationale de la RechercheUK Research and InnovationScience Foundation IrelandAssistance Publique - Hôpitaux de ParisEuropean CommissionFondation de FranceBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchDeutsche ForschungsgemeinschaftKing's College LondonSouth London and Maudsley NHS Foundation TrustKing’s College LondonNational Institutes of HealthFondation de l'Avenir pour la Recherche Médicale Appliquée
KeywordsDNA methylationEpigeneticsPsychologyLongitudinal studyMethylationPsychopathologyEpigenomeClinical psychologyBiologyGeneticsGeneMedicineGene expressionPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.442

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.113
GPT teacher head0.380
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2022
Admission routes1
Has abstractno

Explore more

Same venueBiological PsychiatrySame topicAttention Deficit Hyperactivity DisorderFrench-language works237,207