Study of the in vitro degradation and characterization of the <scp>HaCat</scp> keratinocytes adherence on electrospun scaffolds based polyvinyl alcohol/sodium alginate
Bibliographic record
Abstract
Abstract Biomaterial scaffolds house and direct cells to grow, exposing them to appropriate growth factors. Most of them are designed to degrade at a controlled rate as the new host tissue replaces them. Here, we show that scaffolds obtained through electrospinning of PVA with 3.5, 4.0, and 5.0 wt% of SA showed a gradual degradation rate under physiological conditions during 100 days of incubation. This behavior is proportional to the SA concentration used, with a mass loss of (41%, 47%, and 49% for each system) after 60 days. Moreover, the dielectric properties (EIS) of the scaffolds correlate with their degradation rate throughout the exposition period (100 days), as indicated by the observed decrease in resistance over time. The 4.0 wt% system showed the lowest capacitance value (1.5 10–5 F) and the highest resistance (4.6106 ohm‐cm2) behavior among all concentrations. Additionally, the morphological analysis through SEM and AFM showed a shrank in the surface morphology after the degradation process and determined the degree of roughness (Ra). Higher roughness prior to the cytocompatibility test promoted increased proliferation and adhesion of HaCat cells, as observed in the 4.0 wt% PVA/SA system (1422 nm Ra). These biomaterials have great potential in wound dressing applications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".