First Look into the Use of Fish Scales as a Medium for Multi-Hormone Stress Analyses
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Bibliographic record
Abstract
Recent efforts have provided convincing evidence for the use of fish scale cortisol concentration in the assessment of long-term stress in fishes. However, cortisol alone is not sufficient to fully describe this state of long-term stress. Dehydroepiandrosterone (DHEA) is an androgen with actions that oppose those of cortisol. The means by which DHEA negates the effects of cortisol occurs in part via changes in the metabolism of cortisol to cortisone. The quantitation of cortisol, DHEA and cortisone could therefore provide a more comprehensive assessment of the overall status of physiological stress. As DHEA and cortisone have yet to be quantified within the fish scale, our first objective was to ensure our sample processing protocol for cortisol was applicable to cortisone and DHEA. Following this, we induced a state of long-term stress in goldfish (Carassius auratus). Some degree of elevation in all hormones was observed in the stressed fish scales. Additionally, cortisol and cortisone were significantly elevated in the stressed fish serum in comparison to controls while DHEA was undetectable in either group. Overall, these results suggest that fish scales provide an appropriate medium for the assessment of long-term stress in fishes via the quantitation of relevant steroid hormones.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it