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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial
Bijoy K. Menon, Brian Buck, Nishita Singh, Yan Deschaintre, Mohammed Almekhlafi, Shelagh B. Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, F. Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S. Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M. Demchuk, Sachin Mishra, Laura Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, Grégory Jacquin, Marie‐Christine Camden, Faysal Benali, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn, Grant Stotts, Michael D. Hill, David J. Gladstone, Alexandre Y. Poppe, Arshia Sehgal, Qiao Zhang, Brendan Cord Lethebe, Craig Doram, Ayoola Ademola, Michel Shamy, Carol Kenney, Tolulope T. Sajobi, Richard H. Swartz
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
Bibliographic record
VenueThe Lancet · 2022
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsUniversité LavalHôpital de l'Enfant-JésusCentre hospitalier universitaire de QuébecHealth and Social Services Centre University Institute of Geriatrics of SherbrookeRed Deer Regional HospitalUniversity of ManitobaUniversity of British ColumbiaCentre Hospitalier Universitaire de SherbrookeToronto Western HospitalLondon Health Sciences CentreUniversity of OttawaHamilton Health SciencesUniversity of CalgaryHealth Sciences CentreSt. Michael's HospitalKelowna General HospitalSunnybrook Health Science CentreMcMaster UniversityUniversity of TorontoWestern UniversityMedicine Hat Regional HospitalUniversité de SherbrookeQueen's UniversityCentre Hospitalier de l’Université de MontréalUniversity of SaskatchewanQueen Elizabeth II Health Sciences CentreGrey Nuns Community HospitalFraser HealthUniversity of Alberta
Fundersnot available
KeywordsMedicineTenecteplaseThrombolysisModified Rankin ScaleFibrinolytic agentStroke (engine)Randomized controlled trialPopulationBolus (digestion)Tissue plasminogen activatorSurgeryInternal medicineIschemic strokeMyocardial infarctionIschemia
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.094
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.024
GPT teacher head0.290
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations450
Published2022
Admission routes2
Has abstractno