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Record W4283798291 · doi:10.1016/s0140-6736(22)01054-6

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

2022· article· en· W4283798291 on OpenAlexaffabout
Bijoy K. Menon, Brian Buck, Nishita Singh, Yan Deschaintre, Mohammed Almekhlafi, Shelagh B. Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, F. Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S. Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M. Demchuk, Sachin Mishra, Laura Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, Grégory Jacquin, Marie‐Christine Camden, Faysal Benali, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn, Grant Stotts, Michael D. Hill, David J. Gladstone, Alexandre Y. Poppe, Arshia Sehgal, Qiao Zhang, Brendan Cord Lethebe, Craig Doram, Ayoola Ademola, Michel Shamy, Carol Kenney, Tolulope T. Sajobi, Richard H. Swartz

Bibliographic record

VenueThe Lancet · 2022
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsUniversité LavalHôpital de l'Enfant-JésusCentre hospitalier universitaire de QuébecHealth and Social Services Centre University Institute of Geriatrics of SherbrookeRed Deer Regional HospitalUniversity of ManitobaUniversity of British ColumbiaCentre Hospitalier Universitaire de SherbrookeToronto Western HospitalLondon Health Sciences CentreUniversity of OttawaHamilton Health SciencesUniversity of CalgaryHealth Sciences CentreSt. Michael's HospitalKelowna General HospitalSunnybrook Health Science CentreMcMaster UniversityUniversity of TorontoWestern UniversityMedicine Hat Regional HospitalUniversité de SherbrookeQueen's UniversityCentre Hospitalier de l’Université de MontréalUniversity of SaskatchewanQueen Elizabeth II Health Sciences CentreGrey Nuns Community HospitalFraser HealthUniversity of Alberta
Fundersnot available
KeywordsMedicineTenecteplaseThrombolysisModified Rankin ScaleFibrinolytic agentStroke (engine)Randomized controlled trialPopulationBolus (digestion)Tissue plasminogen activatorSurgeryInternal medicineIschemic strokeMyocardial infarctionIschemia

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.921
Threshold uncertainty score0.157

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.003
Bibliometrics0.0000.001
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.290
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations450
Published2022
Admission routes2
Has abstractno

Explore more

Same venueThe LancetSame topicAcute Ischemic Stroke ManagementFrench-language works237,207