A local activation time histogram—An invaluable tool to diagnose a rare and complex atrial flutter mechanism
Bibliographic record
Abstract
Prior ablation for atrial fibrillation (AF) can predispose patients to the development of atypical atrial flutters, which usually originate from either the left or right atria (LA or RA). Rarely, an atrial flutter circuit can actively involve both atria.1 Herein, we present a case of a macro-reentrant biatrial flutter utilizing Bachmann's bundle as the critical component of the reentrant circuit. A 70-year-old woman with prior history of pulmonary vein isolation, posterior wall isolation, cavotricuspid and anterior mitral flutter line placement for persistent AF presented with recurrent atrial flutter with tachycardia cycle length (TCL) of 250 ms. A local activation timing (LAT) map was created of the left atrium suggesting a breakthrough in the previously created anterior mitral line (Figure 1A, Video S1). An incomplete distribution of the tachycardia cycle length was noted in the LAT histogram. An RA LAT map was created demonstrating a region of “early-meets-late” in the right septum just adjacent to the earliest site in the LA (Figure 1B, Video S2). Again, an incomplete LAT histogram was noted. Careful examination of the LA and RA maps together (Figure 1C, Video S3) demonstrated that the missing portions of the LAT histogram in one chamber were present in the other suggesting the presence of biatrial flutter. We elected to target the earliest site in the LA in the region of Bachman's bundle with progressive cycle length prolongation and then termination. A biatrial flutter is a rare form of atypical flutter (0.5%–2.1%) using interatrial bridges between 2 atria.2 This case highlights that when all portions of an arrhythmia TCL can not be documented in one chamber, one should look for the involvement of other chambers of the heart (alternative atrium in this case, or epicardium) to better define the arrhythmia mechanism, and identify the precise region for arrhythmia termination. Video S1 Video S2 Video S3 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.003 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".