Visualizing the neuroanatomical changes in Han Chinese adulthood: A pseudo-longitudinal study based on age-related large-scale statistical Chinese brain atlases
Bibliographic record
Abstract
Objective: Understanding how brain changes over lifetime provides the basis for new insights into neurophysiology and neuropathology. In this study, we carried out a pseudo-longitudinal study based on age-related Chinese brain atlases (i.e., Chinese2020) constructed from large-scale volumetric brain MRI data collected in normal Han Chinese adults at varying ages. Methods: In order to quantify the deformation and displacement of brains for each voxel as age increases, optical flow algorithm was employed to compute motion vectors between every two consecutive brain templates of the age-related brain atlas, i.e., Chinese2020. Results: Dynamic age-related neuroanatomical changes in a standardized brain space were shown. Overall, our results demonstrate that brain inward deformation (mainly due to atrophy) can appear in adulthood and this trend generally accelerates as age increases, affecting multiple regions including frontal cortex, temporal cortex, parietal cortex, and cerebellum, whereas occipital cortex is least affected by aging, and even showed some degree of outward deformation in the midlife. Conclusion: Our findings indicated more complicated age-related changes instead of a simple trend of brain volume decrease, which may be in line with the recently increasing interests in the age-related cortical complexity with other morphometry measures.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".