The efficacy of radiotherapy in perianal intraepithelial neoplasia grade 3
Bibliographic record
Abstract
OBJECTIVE: To determine the efficacy of radiotherapy in the local control of Perianal Intraepithelial Neoplasia Grade 3 at a single institution. PATIENTS AND METHODS: This retrospective case series consists of 30 patients treated with local radiotherapy (RT) at the British Columbia Cancer Agency between 1997 and 2017. Chart review was performed to abstract data on patient and treatment characteristics. Outcomes evaluated were local control and survival. RESULTS: Of the 30 patients, 5 had local failure, 3 as recurrent in-situ disease, and 2 as invasive disease. Only 1 recurrence occurred before 5 years. Radiotherapy doses ranged from 42.5 – 60 Gy. The actuarial 5 and 10 year local control rates were 96% and 51%, respectively. 3 patients had a treatment break due to acute RT reaction. Of 6 recorded deaths, none was due to anal disease. CONCLUSIONS: Moderate dose local RT is associated with excellent local control of Perianal Intraepithelial Neoplasia Grade 3 with minimal acute toxicity.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".