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Record W4288041950 · doi:10.1101/2022.07.25.22278036

Normative values for body surface gastric mapping evaluations of gastric motility using Gastric Alimetry: spectral analysis

2022· preprint· en· W4288041950 on OpenAlexaff
Chris Varghese, Gabriel Schamberg, Stefan Calder, Stephen Waite, Daniel D. Carson, Daphne Foong, William Wang, Vincent Ho, Jonathan Woodhead, Charlotte Daker, William Xu, Peng Du, Thomas L. Abell, Henry P. Parkman, Jan Tack, Christopher N. Andrews, Gregory O’Grady, Armen A. Gharibans

Bibliographic record

VenuemedRxiv · 2022
Typepreprint
Languageen
FieldMedicine
TopicGastrointestinal motility and disorders
Canadian institutionsUniversity of Calgary
FundersNational Institutes of HealthRoyal Australasian College of Surgeons
KeywordsPercentileConfidence intervalMedicineBody mass indexMealInternal medicinePopulationGastroenterologyNuclear medicineStatisticsMathematics

Abstract

fetched live from OpenAlex

Abstract Introduction Body surface gastric mapping (BSGM) is a new non-invasive test of gastric function. BSGM offers several novel and improved biomarkers of gastric function capable of differentiating patients with overlapping symptom-profiles. The aim of this study was to define normative reference intervals for BSGM spectral metrics in a population of healthy controls. Methods BSGM was performed in healthy controls using Gastric Alimetry (Alimetry, New Zealand) comprising a stretchable high-resolution array (8×8 electrodes; 196 cm 2 ), wearable Reader, and validated symptom-logging App. The evaluation encompassed a fasting baseline (30 min), 482 kCal meal, and 4-hr postprandial recording. Normative reference intervals were calculated for BSGM metrics including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index (GA-RI; a measure of the concentration of power in the gastric frequency band over time), BMI-adjusted amplitude (µV), and fed:fasted amplitude ratio (ff-AR). Data are reported as median and reference interval (5 th and/or 95 th percentiles). Results 110 subjects (55% female, median age 32 (IQR 24 – 50), median BMI 23.8 kg/m 2 (IQR 21.4 – 26.9)) were included. The median Principal Gastric Frequency was 3.04 cpm; reference interval: 2.65 – 3.35 cpm. Median GA-RI was 0.50; reference interval: !0.25. Median BMI-adjusted amplitude was 37.6 µV; reference interval: 20-70 µV. The median ff-AR was 1.85; reference interval !1.08. Higher BMI was associated with a shorter meal-response duration (p=0.014). Conclusions This study provides normative reference intervals for BSGM spectral data that will be used in clinical practice to inform diagnostic interpretations of abnormal gastric function.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.111
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.002
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.005
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.071
GPT teacher head0.350
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations21
Published2022
Admission routes1
Has abstractyes

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