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Record W4293063532 · doi:10.21203/rs.3.rs-1666514/v1

The relationship between the severity of obsessive compulsive disorder (OCD) and Alzheimer's disease (AD) and frontotemporal dementia (FTD)

2022· preprint· en· W4293063532 on OpenAlexaboutno aff
Romina Dadkhah, Hamid Reza Baradaran, Mostafa Almasi‐Dooghaee, Farahnaz Janmohammadi, Mohammadreza Shalbafan, Amirreza Heidari, mina jazayeri

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldPsychology
TopicObsessive-Compulsive Spectrum Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsFrontotemporal dementiaDementiaNeurologyPsychiatryObsessive compulsiveAlzheimer's diseasePsychologyDiseaseCognitionInternal medicineMedicine

Abstract

fetched live from OpenAlex

Abstract Introduction: Given the prevalence of obsessive-compulsive disorder(OCD), we investigated the association between the severity of OCD and Alzheimer's and frontotemporal dementia.Method: This case-control study included patients referred to the dementia clinic of Firoozgar Hospital and the Brain and Cognition Clinic, who had a Montreal Cognitive Assessment (MOCA) test score less than 26 based on assessments of known Alzheimer's or frontotemporal dementia. The control group also consisted of people who referred to the neurology clinic without complaining of psychiatric disorders. For evaluating the severity of OCD we used the Yale – Brown Obsessive Compulsive Scale (Y-BOCS) questionnaire. Results: This study was performed on 13 patients with Alzheimer's disease, 13 patients with FTD and 26 healthy controls. The MOCA score in the two groups of patients was significantly lower than the control group (P <0.001) and is was not statistically significant between the two groups (P> 0.05). The severity of OCD was significantly higher in FTD )25.76±7.16 (and Alzheimer's patients )18.15±9.50( compared to the control group (7.07±5.70) (P <0.001). Also, the severity of OCD was was higher in the FTD group compared to the Alzheimer's group (P = 0.03). Conclusion: Thus, the severity of OCD in the group of FTD and Alzheimer's patients was higher compared to the control group and also the severity of OCD was higher in the FTD group compared to the Alzheimer's group.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.082
GPT teacher head0.411
Teacher spread0.329 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2022
Admission routes1
Has abstractyes

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