Vitamin D receptor gene ApaI polymorphism and susceptibility to osteoporosis in postmenopausal women: A meta-analysis from 22 Studies. Running title: VDR ApaI gene polymorphism and Osteoporosis
Bibliographic record
Abstract
Abstract Objective: The ApaI polymorphism (G>T, rs7975232) of the vitamin D receptor (VDR) gene is located at the 3’-untranslated end, which does not alter the amino acid sequence of the encoded protein but influences gene expression, regulating mRNA stability[1, 2]. Although the role of ApaI in the risk of postmenopausal osteoporosis has been widely researched, the current results have yielded conflacts. Therefore, we performed an updated pooled analysis to provide comprehensive data on the association between VDR ApaI polymorphism and postmenopausal osteoporosis risk. Methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies from the database establishment to August 2021. Articles on the relationship between VDR gene ApaI polymorphism and osteoporosis were searched from the database. Case-control studies containing available genotype frequencies of A/a were chosen. The Newcastle-Ottawa quality assessment scales (NOS) standard was used to evaluate the quality of the literatures that met the inclusion and exclusion criteria. The odds ratio (OR) value with 95% confidence interval (95% CI) was used to assess the strength of this association. According to the heterogeneity, the fixed-effect model or random-effect model was used to combine the effect amount.Results: 22 studies assessed the relationship between ApaI polymorphism and the risk of osteoporosis in postmenopausal women. The comprehensive analyses showed no significant association for ApaI polymorphism with postmenopausal osteoporosis in the overall population, equally valid for Asian and Caucasian subgroups with any genetic model.Conclusion: The present meta-analysis suggests that the VDR ApaI genotype may not affect the risk of postmenopausal osteoporosis in Asians and Caucasians. This is the latest period meta-analysis for the associations between VDR ApaI polymorphism and postmenopausal osteoporosis, as far as we know.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.012 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.014 | 0.035 |
| Bibliometrics | 0.006 | 0.009 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".