The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
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Abstract
BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. FUNDING: Bill & Melinda Gates Foundation.
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The record
- Venue
- The Lancet
- Topic
- Global Cancer Incidence and Screening
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Institute of GeneticsDepartment of Anthropology, University of California, Los AngelesNational Heart, Lung, and Blood InstituteResearch Management Centre, International Islamic University MalaysiaInstituto de Salud Carlos IIIFundação para a Ciência e a TecnologiaNational Health and Medical Research CouncilUniversity of Florida HealthDirectorate for Biological SciencesUniwersytet OpolskiDebre Tabor UniversityGeorge Institute for Global HealthAlfaisal UniversityResearch Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesUniversitas Sam RatulangiUniversity of TlemcenWolkite UniversityUniversiti Sultan Zainal AbidinDepartment of Global Health and Population, Harvard T.H. Chan School of Public HealthImam Abdulrahman Bin Faisal UniversityI.M. Sechenov First Moscow State Medical UniversityHellenic Foundation for Research and InnovationUniwersytet Warmińsko-Mazurski w OlsztynieUniversitas Gadjah MadaAlzahra UniversityXuzhou Medical UniversityGonabad University of Medical SciencesGuy's and St Thomas' NHS Foundation TrustRajarata University of Sri LankaUniversitat Autònoma de BarcelonaScience, Technology and Innovation Commission of Shenzhen MunicipalitySyöpäsäätiöMasarykova UniverzitaWalailak UniversityUniversity of ColomboNovo Nordisk FondenNational Center of Neurology and PsychiatryMekelle UniversityUniversity of Science and Technology of ChinaMarga und Walter Boll-StiftungWuhan University of Science and TechnologyZayed UniversityNational Nutrition and Food Technology Research InstituteTartu ÜlikoolUniversity of TabrizPeking University Third HospitalNorthwestern UniversityInstitute for Advanced Studies in Basic SciencesRajiv Gandhi University of Health SciencesUniversity of the PhilippinesBill and Melinda Gates FoundationUniversidade Federal de Juiz de ForaChina Medical UniversityBrigham and Women's HospitalArak University of Medical SciencesCancer Institute NSWSecretaría Nacional de Ciencia, Tecnología e InnovaciónSamsungApplied Molecular Biosciences UnitPublic Health Foundation of IndiaBauman Moscow State Technical UniversityUniversidade do PortoUmm Al-Qura UniversityUniversity of TsukubaUniversity of South CarolinaQazvin University of Medical SciencesRice UniversitySigrid Juséliuksen SäätiöYonsei University College of MedicineChinese Center for Disease Control and PreventionOulun YliopistoDepartment of Biotechnology, Ministry of Science and Technology, IndiaUniversidad de ChileUniversity of Health and Allied SciencesTufts Medical CenterUniversidade de LisboaShahrekord University of Medical SciencesPirogov Russian National Research Medical UniversityUniwersytet ŁódzkiUniversidade de São PauloUniversity of New South WalesAutoritatea Natională pentru Cercetare StiintificăKermanshah University of Medical SciencesUmeå UniversitetMazandaran University of Medical SciencesShahrekord UniversityBirjand University of Medical SciencesZhejiang UniversityTanta UniversityHamadan University of Medical SciencesUniversitetet i BergenMinistarstvo Prosvete, Nauke i Tehnološkog RazvojaSemmelweis EgyetemUniversiti Kebangsaan MalaysiaYarmouk UniversityYork UniversitySouth Eastern Sydney Local Health DistrictUniversity of Technology SydneyTehran University of Medical Sciences and Health ServicesKuwait UniversityUniversity of DhakaUniversiteit StellenboschTabriz University of Medical SciencesMenzies Institute for Medical ResearchShahroud University of Medical SciencesUniversity of Cape TownKhalifa University of Science, Technology and ResearchInstitute for Health Metrics and EvaluationKing Abdulaziz UniversityKashan University of Medical SciencesEuropean Regional Development FundKarolinska InstitutetUniversità degli Studi di GenovaUniversiti MalayaIsfahan University of Medical SciencesUniversidade Federal de Santa CatarinaQueen Elizabeth Hospital Birmingham CharityConselho Nacional de Desenvolvimento Científico e TecnológicoUniversitat de ValènciaMinistero della SaluteBundesministerium für GesundheitUniversity of Texas Health Science Center at HoustonQatar UniversityMinistry of Higher Education, MalaysiaSistema Nacional de InvestigadoresNational Institutes of HealthBanaras Hindu UniversityIslamic Azad UniversityYonsei UniversityCollege of Science and Engineering, University of MinnesotaMaurice Wilkins Centre for Molecular BiodiscoveryShiraz University of Medical SciencesAin Shams UniversityBundesministerium für Bildung und ForschungCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorUniversity of South AustraliaJawaharlal Institute Of Postgraduate Medical Education and ResearchDepartment of Social Services, Australian GovernmentFlinders UniversityInstitut National de la Santé et de la Recherche MédicaleAmity UniversityInternational Centre for Diarrhoeal Disease Research, BangladeshSyöpäjärjestötMinistério da Ciência, Tecnologia e Ensino SuperiorNord universitetStudent Research Committee, Tabriz University of Medical SciencesLa Trobe UniversityWestfälische Wilhelms-Universität MünsterIndian Council of Medical ResearchShahid Beheshti University of Medical SciencesShiraz UniversityKing's College LondonOhio State UniversityJohns Hopkins UniversityUniversity of WarwickUniversity of St AndrewsUniversity of LeicesterUniversitas PadjadjaranMashhad University of Medical SciencesUniversity of Southern CaliforniaUniversity of Agriculture, FaisalabadAlexander von Humboldt-StiftungTribhuvan UniversityWellcome TrustChandigarh UniversityUniversity of OxfordUnited Arab Emirates UniversityUniversity of GondarZanjan University of Medical SciencesMorehouse School of MedicineBrown UniversityEngineering Research CentersCOMSATS Institute of Information TechnologyUniversity of QueenslandNational Institute for Health and Care ResearchAddis Ababa UniversitySultan Qaboos UniversityUniversity of Occupational and Environmental HealthUniversity of Central PunjabJames Cook UniversityIstituto di Ricerche Farmacologiche Mario Negri - IRCCSBarts CharityWashington University in St. LouisUniversità degli Studi del Piemonte OrientaleMonash UniversityEuropean Social FundTarbiat Modares UniversityYasuj University of Medical SciencesUniversity of ZanjanUniversity of WashingtonUniversity of BristolTehran Heart CenterDilla UniversityAustralian Catholic UniversityRoyal College of Surgeons in IrelandJimma UniversityYale UniversityIran University of Medical SciencesUniversitatea SapientiaUniversitat de BarcelonaMadda Walabu UniversityPublic Health Agency of CanadaCharles Sturt UniversityBahir Dar UniversitySheffield Hallam UniversityShanghai Jiao Tong UniversityKasturba Medical College, ManipalMinisterul Cercetării, Inovării şi DigitalizăriiBirmingham City UniversityUniversidad Peruana Cayetano HerediaCentro de Desarrollo Urbano SustentableZahedan University of Medical SciencesDeutsches KrebsforschungszentrumHarvard UniversityMinistry of Health and Medical EducationHaramaya UniversityQueen Mary University of LondonVanderbilt UniversityNational Institute for Genetic Engineering and BiotechnologyUniwersytet Jagielloński Collegium MedicumSveučilište u ZagrebuJackson State UniversityFogarty International CenterEast Carolina UniversityMoscow Institute of Physics and TechnologyEmory UniversityUniversità di CataniaThe Wellcome Trust DBT India AllianceUniversity of CalcuttaErasmus Universitair Medisch Centrum RotterdamDebreceni EgyetemEesti TeadusagentuurXiamen UniversityChildren's Hospital of PhiladelphiaHamad Medical CorporationNazarbayev UniversityWuhan UniversityAlberta Health ServicesChinese University of Hong KongFlorida Department of HealthGeorgetown UniversityUniversidade da Beira InteriorUniversity of WaterlooUniversity of TasmaniaCity University of Hong KongUniversity of RochesterUniversity of CreteAfrican-German Network of Excellence in ScienceU.S. Department of Veterans AffairsNational Natural Science Foundation of ChinaIndiana University HealthCentre Hospitalier Universitaire VaudoisCleveland ClinicSocial Science Research CouncilFlorida International UniversityKaiser PermanentePublic Health AgencyUniverzita Karlova v PrazeAlborz University of Medical SciencesUniversity of PeshawarLouisiana State UniversityNational Institute for Health Research Southampton Biomedical Research CentreQuaid-i-Azam UniversityHamad Bin Khalifa UniversityLung Foundation AustraliaMorgan State UniversityHealth Effects InstituteNational Cancer InstitutePeking UniversitySecretaria Nacional de Ciencia y TecnologíaCooperativa de Ensino Superior Politécnico e UniversitárioKrishna Institute Of Medical Sciences Deemed To Be University
- Keywords
- Burden of diseaseMedicineDisease burdenAttributable riskDiseaseEnvironmental healthGlobal healthPublic healthInternal medicinePathologyPopulation
- Has abstract in OpenAlex
- yes