A self-supervised contrastive learning approach for whole slide image representation in digital pathology
Bibliographic record
Abstract
Image analysis in digital pathology has proven to be one of the most challenging fields in medical imaging for AI-driven classification and search tasks. Due to their gigapixel dimensions, whole slide images (WSIs) are difficult to represent for computational pathology. Self-supervised learning (SSL) has recently demonstrated excellent performance in learning effective representations on pretext objectives, which may improve the generalizations of downstream tasks. Previous self-supervised representation methods rely on patch selection and classification such that the effect of SSL on end-to-end WSI representation is not investigated. In contrast to existing augmentation-based SSL methods, this paper proposes a novel self-supervised learning scheme based on the available primary site information. We also design a fully supervised contrastive learning setup to increase the robustness of the representations for WSI classification and search for both pretext and downstream tasks. We trained and evaluated the model on more than 6000 WSIs from The Cancer Genome Atlas (TCGA) repository provided by the National Cancer Institute. The proposed architecture achieved excellent results on most primary sites and cancer subtypes. We also achieved the best result on validation on a lung cancer classification task.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".