Thirteenth International Congress on Spondyloarthritides
Bibliographic record
Abstract
Over the past ten years drugs targeting of the Janus kinases (JAKs) have entered the clinical armamentarium and first generation pan-JAK inhibitors (JAKi) are now used worldwide for the treatment of autoimmune diseases as well as malignancies.Studies on the mechanism of action of successful JAK inhibitors have revealed that, besides T and B cells, they act on innate immune cells and can promote tolerance.For this reason, JAKi are proving to be useful for a variety of immunological diseases ranging from hematological malignancies, rheumatoid arthritis, psoriatic arthritis, diabetic nephropathies, alopecia to rare inflammatory diseases.More selective, second-generation JAKi are now being developed and some have already reached the late stages of clinical development for several of immune-mediated pathologies I will review the most recent findings related to JAKis' mechanism of action, discuss their role in Spondyloarthritis and some of the newest diseases for which inhibition of the JAK-STAT pathway is proving to be a successful therapeutic approach or is being actively investigated. INV3
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".