Thirteenth International Congress on Spondyloarthritides
Bibliographic record
Abstract
Over the past ten years drugs targeting of the Janus kinases (JAKs) have entered the clinical armamentarium and first generation pan-JAK inhibitors (JAKi) are now used worldwide for the treatment of autoimmune diseases as well as malignancies.Studies on the mechanism of action of successful JAK inhibitors have revealed that, besides T and B cells, they act on innate immune cells and can promote tolerance.For this reason, JAKi are proving to be useful for a variety of immunological diseases ranging from hematological malignancies, rheumatoid arthritis, psoriatic arthritis, diabetic nephropathies, alopecia to rare inflammatory diseases.More selective, second-generation JAKi are now being developed and some have already reached the late stages of clinical development for several of immune-mediated pathologies I will review the most recent findings related to JAKis' mechanism of action, discuss their role in Spondyloarthritis and some of the newest diseases for which inhibition of the JAK-STAT pathway is proving to be a successful therapeutic approach or is being actively investigated. INV3
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.085 | 0.057 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".