Rates of osmotic demyelination after rapid correction of sodium in hyponatremia, a multicenter cohort study of patients hospitalized with hyponatremia
Bibliographic record
Abstract
ABSTRACT Background Osmotic demyelination syndrome (ODS) is a rare but devastating complication of rapid correction of hyponatremia. Current guidelines recommend limiting the sodium correction rate to no more than 8 mmol/L per 24 hours, but this is based on expert opinion and small observational studies. Methods We conducted a multicenter cohort study of patients admitted into hospital with hyponatremia at five academic hospitals in Toronto between April 1, 2010 and December 31, 2019. We identified all adult patients with hyponatremia (sodium <130 mmol/L) based on their initial serum sodium measured on presentation to the emergency department. The primary outcome was the rate of ODS. ODS cases were identified using medical record review and neuroimaging results. The secondary outcome was the rate of rapid correction of sodium (>8 mmol/L in any 24-hour period). Results Our cohort included 21182 hospitalizations with hyponatremia. Approximately 50% were women, the average age was 68 years, and mean initial sodium was 124.6 mmol/L (SD 4.6) including 13.1% with sodium <120 mmol/L. Overall, rapid correction of sodium occurred in 3438 (17.9%) admissions. Despite the fact that 3438 experienced rapid correction, there were only 12 cases of ODS among our 21182 hospitalizations with hyponatremia. Cases of ODS had a markedly lower initial serum sodium (110.7 vs. 124.6 mmol/L), were younger (50 years vs 68 years), were more likely to have alcohol use disorder, and were more likely to have hypokalemia (58% vs 14%) compared to those without ODS. Conclusions In the large multicenter study of patients with hyponatremia, “rapid” overcorrection was common (N=3438, 17.9%) but ODS was rare (N=12, 0.06%). The initial serum sodium was markedly lower for those with ODS compared to those without. Taken together, these results suggest that the severity of hyponatremia is a more important risk factor for ODS then the rate of correction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".