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Record W4294556311 · doi:10.1056/nejme2210347

RETHINCking COPD — Bronchodilators for Symptomatic Tobacco-Exposed Persons with Preserved Lung Function?

2022· letter· en· W4294556311 on OpenAlexaff
Don D. Sin

Bibliographic record

VenueNew England Journal of Medicine · 2022
Typeletter
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsSt. Paul's Hospital
Fundersnot available
KeywordsMedicineCOPDSpirometryPulmonary diseaseSmoking historySmall airwaysCigarette smokingLung functionPulmonary function testingRespiratory systemCigarette smokeSmokeLungTobacco smokeIntensive care medicineInternal medicineAsthmaEnvironmental health

Abstract

fetched live from OpenAlex

Cigarette smoking is the leading global cause of chronic obstructive pulmonary disease (COPD). Worldwide, more than 1.3 billion persons smoke and 384 million persons have COPD.1 COPD is clinically diagnosed on the basis of persistent airflow limitation as measured by spirometry in persons with a history of smoking who have frequent respiratory symptoms.2 One major limitation of spirometry is that the values it measures mostly reflect pathologic processes in the large airways. However, in COPD, the disease begins in the small airways (i.e., airways <2 mm in diameter); these airways are inflamed, narrowed, and then destroyed in response to long-term . . .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: none
Teacher disagreement score0.033
Threshold uncertainty score0.021

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.012
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0020.002
Scholarly communication0.0020.005
Open science0.0020.001
Research integrity0.0330.021
Insufficient payload (model declined to judge)0.0060.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.290
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2022
Admission routes1
Has abstractyes

Explore more

Same venueNew England Journal of Medicine→Same topicChronic Obstructive Pulmonary Disease (COPD) Research→French-language works237,207→