EP09.03: Obliterated cavum septum pellucidum: a normal variant?
Bibliographic record
Abstract
We report a case of a 39-year-old woman seen at 12 weeks with a fetal nuchal translucency between the 95°-99° centile. At 20 weeks an obliterated and hyperechoic CSP and a “hook-shaped” gallbladder were observed (figure1a-1b). Fetal magnetic resonance (MRI) showed left polymicrogyria (figure1c-1d). Standard karyotype and array analysis were normal. A non-complicated Caesarean section was performed due to labour dystocia. Apgar score was unexpectedly low, and the umbilical cord pH was 6.7 with -23 base excess. Epilepsy, refractory to combined antiepileptic drugs therapy, developed. Postnatal MRI showed signs of severe damage at the level of the left cerebral hemisphere and basal ganglia with abnormal cortical thickness and configuration, abnormal white matter signal and an enlarged left ventricle (figure 1e-1d). The baby developed acute kidney failure and died at four days of life. Postmortem autopsy confirmed the prenatal findings and found multiple visceral peritoneal adherences that explained the “hook-shaped” gallbladder. A whole-exome sequencing (WES) analysis was performed and showed a de novo PTEN pathogenic variant: c.697C>T (p.Arg233Ter). Counselling in the presence of obliterated CSP is still uncertain and further research is needed. Fetal MRI should be considered in the presence of an obliterated CSP associated to minor and/or major additional findings. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.006 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".