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Record W4297231406 · doi:10.1016/s1474-4422(22)00200-9

Diagnosis and classification of optic neuritis

2022· review· en· W4297231406 on OpenAlexaff
Axel Petzold, Mathias Abegg, Raed Alroughani, Daniah Alshowaeir, Regina Maria Papais Alvarenga, Cécile Andris, Nasrin Asgari, Yael Barnett, Roberto Battistella, Raed Behbehani, Thomas Berger, Mukharram M. Bikbov, Damien Biotti, Valérie Biousse, Antonella Boschi, Milan Brazdil, A. Yu. Brezhnev, Peter A. Calabresi, Monique Cordonnier, Fiona Costello, Franz Marie Cruz, Leonardo Provetti Cunha, Smail Daoudi, Romain Deschamps, de Sèze, Ricarda Diem, Masoud Etemadifar, José Flores‐Rivera, Pedro Fonseca, Jette Lautrup Frederiksen, Elliot M. Frohman, Teresa C. Frohman, Caroline Tilikete, Kazuo Fujihara, Alberto Gálvez, Riadh Gouider, Fernando Gracia, Nikolaos Grigoriadis, J. Guajardo, Mario Habek, Marko Hawlina, Elena H. Martínez‐Lapiscina, Juzar Hooker, Jyh Yung Hor, William Howlett, Yu-Min Huang, Zhannat Idrissova, Zsolt Illés, Jasna Jančić, Panitha Jindahra, Dimitrios Karussis, Emı́lia Kerty, Ho Jin Kim, Wolf A. Lagrèze, Letizia Leocani, Petra Lišková, Yaou Liu, Youssoufa Maiga, Romain Marignier, Chris McGuigan, Dália Meira, H. Merle, Mário Luiz Ribeiro Monteiro, Anand Moodley, Frederico Castelo Moura, Silvia Muñoz, Sharik Mustafa, Ichiro Nakashima, Susana Noval, Carlos Oehninger, Olufunmilola Ogun, Afekhide Omoti, Lekha Pandit, Friedemann Paul, Gema Rebolleda, Stephen Reddel, Konrad Rejdak, Robert Ręjdak, Alfonso J. Rodríguez‐Morales, Marie‐Bénédicte Rougier, María José Sá, Bernardo Sánchez‐Dalmau, Deanna Saylor, Ismail Shatriah, Aksel Sıva, Hadas Stiebel‐Kalish, Gabriella Szatmáry, Linh Ta, Silvia Tenembaum, Huy Tran, Yevgen Trufanov, Vincent Van Pesch, An-Guor Wang, Mike P. Wattjes, Ernest Willoughby, Magd Zakaria, Jasmin Zvorničanin, Laura J. Balcer, Gordon T. Plant

Bibliographic record

VenueThe Lancet Neurology · 2022
Typereview
Languageen
FieldMedicine
TopicMultiple Sclerosis Research Studies
Canadian institutionsUniversity of AlbertaUniversity of Calgary
FundersChugai PharmaceuticalNational Institute of Neurological Disorders and StrokeIXICONational Institute of Mental HealthSanofi GenzymeDaewoong Pharmaceutical CompanySanofiMultiple Sclerosis International FederationNational Institute on AgingCSL BehringMinistry of Education, Science and TechnologyCelltrionEisaiHandokTeva Pharmaceutical IndustriesNational Research Foundation of KoreaNational Multiple Sclerosis SocietyVrije Universiteit AmsterdamNational Research FoundationUniversity College LondonMultiple Sclerosis SocietyEuropean Committee for Treatment and Research in Multiple SclerosisFondation CharcotBiogenCelgeneBundesministerium für Bildung und ForschungU.S. Department of StateDeutsche ForschungsgemeinschaftAlexion Pharmaceuticals
KeywordsOptic neuritisMedicineMyelin oligodendrocyte glycoproteinMultiple sclerosisNeuromyelitis opticaOptic nerveOphthalmologyImmunology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.014
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.010
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.004
Bibliometrics0.0090.006
Science and technology studies0.0000.001
Scholarly communication0.0020.002
Open science0.0030.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.303
GPT teacher head0.421
Teacher spread0.118 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations293
Published2022
Admission routes1
Has abstractno

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