Stability Over Time of In-Hospital–Compounded Amoxicillin Capsules and Ceftriaxone Patch Tests for Drug Allergy Testing
Bibliographic record
Abstract
Extended materials and methods 1-ReagentsAmoxicillin (Clamoxyl® 500 mg) and ceftriaxone (Ceftriaxone 1g Mylan®, powder for solution for injection) were respectively purchased from GlaxoSmithKline (Brentford, United Kingdom) and Mylan (Canonsburg, Pennsylvania, USA).Colloidal silica, petrolatum and carmine powder were obtained from Cooper (Melun, France).Sterile water was purchased from BBraun (Melsungen, Germany).Chemicals and reagents used for HPLC-MS/MS were all of analytical grades and included water, methanol and acetonitrile purchased from Carlo Erba (Fontenay-aux-Roses, France).Formic acid, and ammonium formiate were purchased from VWR Chemicals (Leuven, Belgium).Amoxicillin-d4 and ceftriaxone-d4 were purchased from Toronto Research Chemicals (Toronto, Canada). 2-Analytical method 2-1-Chromatographic conditionsAmoxicillin and Ceftriaxone were determined by liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) using a Shimadzu prominence HPLC system (Shimadzu®, Kyoto, Japan) coupled to a 4500 QTRAP triple quadrupole mass spectrometer (Sciex®, Framingham, Massachusetts, USA), equipped with an electrospray ionization source operating in the positive ion mode.An Alltima HP C18 HL 3μm 150 × 3 mm column (Alltech®, Grace Discovery Sciences) was maintained at 30°C with a flow rate of 0.6 mL/min for 5.5 minutes using an elution gradient.The mobile phase consisted of 30% methanol with 0.2% formic acid from acetonitrile and 70% 2 mM ammonium formiate with 0.2% formic acid in water (70/30
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".