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Record W4300711554 · doi:10.17615/dd4v-2733

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

2020· article· en· W4300711554 on OpenAlexfundno aff
Wim de Kort, Hans Wildiers, Giuseppe Floris, Manjeet K. Bolla, Xiao‐Ou Shu, Diether Lambrechts, Kamila Czene, Chun Li, Ryan Delahanty, Sune F. Nielsen, Mitul Shah, Mikael Eriksson, Jirong Long, Børge G. Nordestgaard, Matti A. Rookus, Qin Wang, Janet E. Olson, Ben Zhang, Fergus J. Couch, Chenjie Zeng, Marjanka K. Schmidt, Jenny Chang‐Claude, Patrick Neven, Stig E. Bojesen, Joe Dennis, Alison M. Dunning, Henrik Flyger, Katja van den Hurk, Barbara Perkins, Wanqing Wen, Hatef Darabi, Kyriaki Michailidou

Bibliographic record

VenueKölner Universitäts PublikationsServer (Universität zu Köln) · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsnot available
FundersMedical Research and Materiel CommandUniversitätsklinikum Hamburg-EppendorfCancer Council TasmaniaNational Health and Medical Research CouncilMedical Research CouncilUniversity of California, IrvineRheinische Friedrich-Wilhelms-Universität BonnMinistero dello Sviluppo EconomicoCancer Council VictoriaOulun YliopistoDeutsche KrebshilfeMedizinischen Hochschule HannoverNorges ForskningsrådStockholms Läns LandstingNational Cancer InstituteKuopion Yliopistollinen SairaalaKarolinska InstitutetCanadian Institutes of Health ResearchCancerfondenBundesministerium für Bildung und ForschungNational Breast Cancer FoundationGénome QuébecAcademy of FinlandUniversity of Southern CaliforniaBeckman Research Institute, City of HopeCancer Research UKEberhard Karls Universität TübingenFondation du cancer du sein du QuébecMinistère du Développement Économique, de l’Innovation et de l’ExportationDeutsches KrebsforschungszentrumNational Institutes of HealthDeutsche Gesetzliche UnfallversicherungDavid F. and Margaret T. Grohne Family FoundationMcGill University Health CentreMcGill UniversityRobert Bosch StiftungHelsingin ja Uudenmaan SairaanhoitopiiriMinisterio de Economía y CompetitividadVanderbilt UniversityOvarian Cancer Research FundU.S. ArmyMayo ClinicBreast Cancer Research FoundationAssociazione Italiana per la Ricerca sul CancroItä-Suomen Yliopisto
KeywordsMendelian randomizationBreast cancerMedicineOncologyCancerRandomizationProspective cohort studyInternal medicineRandomized controlled trialGeneticsBiologyGeneGenetic variantsGenotype

Abstract

fetched live from OpenAlex

Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.032
metaresearch head score (Gemma)0.095
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.032
Threshold uncertainty score0.170

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0320.095
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.003
Bibliometrics0.0020.004
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.246
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2020
Admission routes1
Has abstractyes

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