The Mystery of Rhomboid in Capicua mutant Fruit Flies
Bibliographic record
Abstract
Drosophila melanogaster is a fruit fly that is one of the most commonly used animal model for genetic studies.
 Dorsal-ventral (dv) patterning, which is the body plan, of the Drosophila embryo is determined by the asymmetric positioning of different underlying cellular molecules. DV patterning of the Drosophila embryo is established well before fertilisation. The Drosophila egg develop within a cluster of cells consisting of an oocyte interconnected with fifteen sister nurse cells, which function as a source of RNAs and proteins for the developing oocyte and degenerate by the end of oogenesis. Surrounding this cluster is an epithelium of follicle cells, which provide yolk and secrete the eggshell (Fig1).
 Initial dv asymmetry is established at mid oogenesis and the information is then passed on to the surrounding follicle cells (3). The protein gurken (grk), in the oocyte, provides the initial polarizing signal to initiate the formation of the eventual polarity of the egg, and activates Drosophila epidermal growth factor receptor (EGFR) signaling in the dorsal follicle cells. Through positive and negative feedback mechanisms, this EGF signaling is refined and defines a precise pattern of cell fates within the follicular epithelium (3). This specific definition of fates will be used as a basis to understand the effects of the gene capicua (cic) on follicle cell fate patterning.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".