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Carotenoids and Carcinogenesis: Exploring the Antioxidant and Cell Signaling Roles of Carotenoids in the Prevention of Cancer

2022· review· en· W4301354872 on OpenAlexaff
Nikolina Vrdoljak

Bibliographic record

VenueCritical Reviews™ in Oncogenesis · 2022
Typereview
Languageen
FieldMedicine
TopicAntioxidant Activity and Oxidative Stress
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsCarotenoidZeaxanthinLuteinLycopeneCarcinogenesisAntioxidantCancerCancer preventionFucoxanthinBiochemistryBiologyChemistryFood scienceGenetics

Abstract

fetched live from OpenAlex

Carotenoids are lipid soluble pigments found in various fruits and vegetables and are naturally produced in photoautotrophic plants. Various studies have investigated the properties of carotenoids to determine how they are able to mitigate numerous diseases, including cancer. Carotenoids present in human serum, including β-carotene, α-carotene, lycopene, β-cryptoxanthin, zeaxanthin, and lutein have demonstrated the ability to act as anticarcinogenic agents. Prevention of disease is often described to be more effective than treatment; as cancer impacts millions of lives globally, the role of carotenoids in the prevention of oncogenesis for numerous types of cancers have been extensively researched. This review provides an in-depth analysis of the structure and properties of carotenoids, as well as the identified and potential mechanisms by which carotenoids can act as a chemopreventative agent.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.161
GPT teacher head0.401
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2022
Admission routes1
Has abstractyes

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Same venueCritical Reviews™ in OncogenesisSame topicAntioxidant Activity and Oxidative StressFrench-language works237,207