Gastroenterology, hepatology, and nutrition
Bibliographic record
Abstract
Aim: In addition to acid gastro-oesophageal reflux (GOR), non-acid GOR (pH > 4) may be clinically relevant in neurologically impaired children.However, standard pH metry can only detect the former.The aim of this study was to quantify acid and non-acid reflux in a group of these patients using a new catheter-related technique.Methods: Ten children (9 cerebral palsy, 1 Trisomy 21) fed intragastrically underwent 12 hour studies of intra-oesophageal 6 channel impedance and dual channel pH monitoring.All patients were off medication influencing gastric pH.Recordings were analyzed for the frequency of acid and non-acid GOR and the height reached by the refluxate.Results: Three hundred and sixty nine reflux events were detected with the combined technique.One hundred and ninety one (51.8%)were non-acid events (mean pH 5.6) and of these 138 (72.2%) reached the uppermost (1) impedance channel.Of the 178 acid reflux events (mean pH 3.1), 81.5% reached the uppermost channel.Conclusions: Over half of reflux events in neurologically impaired children are non-acidic and therefore are missed using standard pH metry.Most of these refluxes reached the upper oesophagus.Simultaneous intraoesophageal impedance and pH measurements proves to add valuable information that may improve therapeutic management in this patient group.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.029 | 0.006 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".