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Record W4304202865 · doi:10.21203/rs.3.rs-2130802/v1

Genome-wide identification and characterization of Glutathione S-transferase gene family in Cajanus cajan and their expression profiling under different developmental stages in anatomical tissues

2022· preprint· en· W4304202865 on OpenAlexaff
Swati Vaish, Divya Gupta, Muskan Jain, Mansi Verma, Abhishek Prakash, Nootan Singh, Mohd Akram Ansari, Gurjeet Kaur, Mahesh Kumar Basantani

Bibliographic record

VenueResearch Square · 2022
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGlutathione Transferases and Polymorphisms
Canadian institutionsMemorial University of Newfoundland
Fundersnot available
KeywordsCajanusBiologyGeneGene expression profilingGene duplicationGene familyGeneticsGene expressionGlutathione S-transferaseBiochemistryGlutathioneEnzyme

Abstract

fetched live from OpenAlex

Abstract Plant glutathione S-transferases (GSTs) are multifunctional conserved protein superfamily that is involved in various biological processes such as growth and development, cellular detoxification, stress biology, and various signaling processes. In the current study, a comprehensive genome-wide identification and characterization of the GST gene family were performed in the agriculturally important legume crop Cajanus cajan. A total of 68 GST genes were identified that belong to eight GST classes based on their conserved domains and motifs. Among 68 CcGST genes, 37 CcGST genes were found on seven Cajanus chromosomes and the remaining CcGST genes were found on the scaffold. Segmental and tandem duplication, both were the driving forces of CcGST gene family expansion. The conserved pattern of exon and intron structure among the different GST classes was observed. The secondary prediction showed the dominance of α- helices. Ser is the highly phosphorylated site in CcGSTs. The subcellular localization prediction of CcGSTs revealed their dominance in the cytoplasm. The physicochemical properties of major CcGST proteins reveal that they are acidic in nature. The expression profiling study revealed the high expression of CcGSTU38, CcGSTU40, CcGSTU44, CcGSTL3, CcGSTL4, CcEF1G1, CcEF1G2, CcDHAR2 and CcGSTF6 in most of the developmental stages in different anatomical tissues. The molecular docking study of highly expressed CcGSTU38 with eight herbicide safeners revealed its highest binding affinity with Fenclorim (-5.44 kcal/mol). This gene could be a potential candidate for future molecular characterization under herbicide stress. The results of the current study endow us with the further functional analysis of Cajanus GSTs in the future.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.374
Threshold uncertainty score0.943

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.314
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2022
Admission routes1
Has abstractyes

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