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Record W4306158070 · doi:10.1038/s41379-022-01165-w

Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

2022· article· en· W4306158070 on OpenAlexafffund
Emily F. Thompson, Jutta Huvila, Amy Jamieson, Samuel Leung, Amy Lum, Saul Offman, Alice Lytwyn, Mona Lisa Sur, Lynn Hoang, Julie Irving, Nicholas van der Westhuizen, Chantale Morin, Cyrille Bicamumpaka, Nazilla Azordegan, F. Gougeon, Kaoutar Ennour‐Idrissi, Janine Senz, Melissa K. McConechy, Rosalía Aguirre-Hernández, Victoria Lui, Carolyn Kuo, Cassidy Bell, Taylor Salisbury, James Lawson, Ellen He, Shanzhao Wang, Derek S. Chiu, Sarah Kean, Vanessa Samouëlian, Shannon Salvador, Walter H. Gotlieb, Limor Helpman, Stephanie Scott, Christoph Wohlmuth, Danielle Vicus, Marie Plante, Aline Talhouk, David G. Huntsman, Carlos Parra‐Herran, Mary Kinloch, Katherine Grondin, C. Blake Gilks, Jessica N. McAlpine, Anita Agrawal, Omar Al‐Nourhji, Alon D. Altman, Marcus Q. Bernardini, Mark Carey, Blaise Clarke, Nazila Azordegan, Bojana Djordjevic, Laurie Elit, Alex Ferenczy, Sarah Finlayson, Anthony Fyles, Hugo Garneau, France Gauthier, Prafull Ghatage, Kathy Han, Hal W. Hirte, Fleur Huang, Katharina Kieser, Mary Kinlloch, Iwa Kong, Aalok Kumar, Janice S. Kwon, Sandra Lee, Eric Leung, Helen Mackay, Eve‐Lyne Marchand, Justin Mcginnis, Dianne Miller, Gregg Nelson, Manuela Pelmus, Annick Pina, Anna Plotkin, Diane Provencher, Anna V. Tinker, Alicia Tone, Stephen Welch, Nicholas Westhuizen, Katarzyna J. Jerzak

Bibliographic record

VenueModern Pathology · 2022
Typearticle
Languageen
FieldMedicine
TopicEndometrial and Cervical Cancer Treatments
Canadian institutionsUniversity of AlbertaSaskatoon City HospitalHealth Sciences CentreWestern UniversityUniversity of TorontoMcGill UniversityUniversité de MontréalUniversity of SaskatchewanOvarian Cancer CanadaUniversité LavalCentre Hospitalier de l’Université de MontréalHôtel-Dieu de QuébecUniversity of ManitobaCentre hospitalier universitaire de QuébecUniversity of CalgaryVancouver General HospitalJuravinski HospitalMcMaster UniversityDalhousie UniversitySunnybrook Health Science CentreJewish General HospitalCentre for Advancing Health OutcomesUniversity of British Columbia
FundersCanadian Institutes of Health ResearchMichael Smith Health Research BC
KeywordsMedicineSerous fluidImmunohistochemistrySerous carcinomaMolecular pathologyCohortEndometrial cancerInternal medicineOncologyRetrospective cohort studySerous membranePathologyStage (stratigraphy)CarcinomaSurgical pathologyCancerAnatomical pathologyBiologyOvarian cancerGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.562
Threshold uncertainty score0.610

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.074
GPT teacher head0.319
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designOther design
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations47
Published2022
Admission routes2
Has abstractno

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