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Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial
Ingrid M. Bistervels, Andréa Buchmuller, Hanke M.G. Wiegers, Fionnuala Ní Áinle, Bernard Tardy, Jennifer Donnelly, Peter Verhamme, Anne Flem Jacobsen, Anette Tarp Hansen, Marc Rodger, Maria T. DeSancho, R.G. Shmakov, Nick van Es, Martin H. Prins, Céline Chauleur, Saskia Middeldorp, Eline S. van den Akker, Mireille N. Bekker, Thomas van Bemmel, Laurent Bertoletti, Julie Blanc, Suzanne M. Bleker, Aude Bourtembourg-Matras, Florence Bretelle, B. Byrne, Françis Couturaud, Pierre Delorme, Elise S. Eerenberg, Maureen TM Franssen, Jens Fuglsang, Wessel Ganzevoort, François Goffinet, Jiska M de Haan-Jebbink, Wieteke M. Heidema, Monique A Hertzberg, Marcel M.C. Hovens, Menno V. Huisman, Leonie de Jong-Speksnijder, Pieter W. Kamphuisen, Denis J O'Keeffe, Karine Lacut, Josje Langenveld, M Simone Lunshof, Caroline P. Martens, A. Merah, Emmanuelle Le Moigne, Dimitri N.M. Papatsonis, Gilles Pernod, F. Perrotin, Edith Peynaud-Debayle, Fabrice Pierre, Geneviève Bureau, Tiphaïne Raia-Barjat, Robbert JP Rijnders, Roger Rosario, M. Ruivard, Jeannot Schmidt, Marieke Sueters, Thomas Vanassche, Marie-Noëlle Varlet, Alexandre Vivanti, Matthieu Y. van der Vlist, Lucet F. van der Voet, Karlijn C. Vollebregt, Johanna I. de Vries, Sabina de Weerd, Peter E. Westerweel, Lia DE Wijnberger, Marije ten Wolde, Paula F. Ypma, Catherine Zuily-Lamy, Joost J. Zwart, Alexandra Benachi, G. Beucher, H. Bézanahary, Karin Boer, Marjon A. de Boer, Frantz Bousquet, Henk A. Bremer, Luc Bressollette, Aurélie Brossard, Cécile Chau, Brian Cleary, Fabienne Comte, Thomas Corsini, Anne Coustel, Barbara Debaveye, Raoul Desbrière, Cécile Duvillard, A. Eckman, Jeroen Eikenboom, Antoine Élias, Laura M. Faber, Émile Ferrari, Denis Gallot, Emilie Gauchotte, Ingrid Gaugler, Abby E. Geerlings, Audrey O'Gorman, Vincent Grobost, Pieter-Kees de Groot, David P. van der Ham, Brenda Hermsen, Kim Kamphorst, Alan Karovitch, Gunilla Kleiverda, Aiste Kloster, Annemarieke Koops, Inneke Krabbendam, Marieke J.H.A. Kruip, Saskia Kuipers, Judith van Laar, Damien Lanéelle, Suzanne Lima, Peter MacMahon, Laurent Mandelbrot, Claudia A van Meir, C. Menez, Leonard P. Morssink, Nathalie Moulin, E. Mousty, Matthieu Muller, Lucy Eldersveld Murphy, Kathelijne Peerlinck, Alma O'Reilly, Maartje de Reus, Magali Hilmi Le Roux, Kevin M. Ryan, Bettina Samren, Daniela H. Schippers, Nico Schuitemaker, Chloé Schweizer, Hanneke van der Straaten, Cécile Tromeur, Kristine Vanheule, Tamara Verhagen, Jantien Visser, Michael R. Watts, Wim J. van Wijngaarden, Mallory Woiski, Maartje Zelis
Bibliographic record
VenueThe Lancet · 2022
Typearticle
Languageen
FieldMedicine
TopicBlood Coagulation and Thrombosis Mechanisms
Canadian institutionsOttawa Hospital
FundersPfizer
KeywordsMedicinePost partumLow molecular weight heparinVenous thromboembolismHeparinObstetricsRandomized controlled trialPregnancySurgeryThrombosis
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.731
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.033
GPT teacher head0.288
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations111
Published2022
Admission routes1
Has abstractno