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Record W4309362702 · doi:10.1503/cmaj.212063

Core elements of participant consent documents for Canadian human genomics research and the National Human Genome Library: guidance for policy

2022· article· en· W4309362702 on OpenAlexafffundvenueabout
Holly Longstaff, Jaime Flamenbaum, Étienne Richer, Jeanne Egar, Christopher McMaster, Ma’n H. Zawati

Bibliographic record

VenueCanadian Medical Association Journal · 2022
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsInstitute of Health Services and Policy ResearchMcGill University Health CentreSimon Fraser UniversityCanadian Institutes of Health ResearchProvincial Health Services Authority
FundersInstitute of GeneticsCanadian Institutes of Health Research
KeywordsHuman genomeGenomicsInformed consentHealth careKey (lock)PopulationLibrary scienceWorld Wide WebComputer scienceGenomeData scienceMedicinePolitical scienceAlternative medicineGeneticsGeneBiologyLawPathologyEnvironmental health

Abstract

fetched live from OpenAlex

[See related article at www.cmaj.ca/lookup/doi/10.1503/cmaj.221500][1] KEY POINTS Human genomics — the study of the entirety of a person’s or population’s genes — is increasingly being integrated into research and rapidly incorporated into clinical care, including into health records.[1][2

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.237
metaresearch head score (Gemma)0.316
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.965
Threshold uncertainty score0.941

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2370.316
Meta-epidemiology (narrow)0.0020.006
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0070.010
Science and technology studies0.0160.011
Scholarly communication0.0130.010
Open science0.0120.009
Research integrity0.0480.023
Insufficient payload (model declined to judge)0.1380.093

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.579
GPT teacher head0.583
Teacher spread0.004 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designObservational
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2022
Admission routes4
Has abstractyes

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Same venueCanadian Medical Association JournalSame topicEthics in Clinical ResearchFrench-language works237,207