Contemporary aetiologies of medical complexity in children: a cohort study
Bibliographic record
Abstract
PostScriptwith infants without symptoms in the period of 1-14 days post vaccination.CRP among symptomatic children was similar in the period of 1-7 days post vaccination (p=0.81) and marginally higher than asymptomatic infants 8-14 days post vaccination (adjusted mean difference 1.72 mg/L; 95% CI 1.10 to 2.69, p=0.018).Among 2.7% (9/339) infants with CRP of >50 mg/L, none required hospitalisation.Limitations include small samples (particularly 0-14 days prevaccination), selection bias and the range of vaccines.A CRP rise in the 7-day postvaccination period was demonstrated, complementing high-income studies.4 Elsewhere, immunogenic vaccines requiring paracetamol, such as meningococcal B, are associated with significant CRP rise; therefore, a robust CRP immune response is expected.3 In several infants, CRP concentrations were extremely elevated (maximum 148 mg/L, asymptomatic).When restricting to asymptomatic children, the association remained.Infants with bacterial infections have been identified in the week post vaccination, and testing for infections is recommended.8 However, CRP alone may be a poor discriminator of illness post vaccination and should not replace clinical judgement.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".