Development and implementation of a concept for substitution of the highly hazardous substances with safe chemical alternatives
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Introduction. The concept of chemical substitution is now increasingly included in policy and regulatory efforts around the world to reduce the risks of chemicals to human health and the environment, as well as in industry initiatives for the sustainable management of chemicals. With the exception of conventional substances regulated by EEC documents, unfortunately, there is no legislatively established mechanism for identifying, banning and limiting the production and consumption of highly hazardous chemical compounds in the Russian Federation. The purpose of the research is to develop and scientifically substantiate the concept of replacing highly hazardous chemicals with safer alternatives. Materials and methods. The guidelines and recommendations of the OECD, WHO, ILO, FAO, UNEP, as well as regulatory and methodological documents of the EU, the USA, Canada and other states on the criteria for classifying substances as highly hazardous, organizing and monitoring them in environmental objects and selection of safe chemical alternatives were studied and analyzed. Results. The concept of substitution includes the scientific substantiation of the criteria for classifying substances as highly hazardous, the organization and generalization of data from monitoring the human environment and the circulation of hazardous chemical products on the market, the development of a list of highly hazardous chemicals that are priority for regulation; selection of safe alternatives and their comparative analysis, taking into account the assessment of the advantages of the alternative over the existing technology/substance, implementation of management decisions. The criteria for identifying substances of highly concern and selecting their alternatives are the following indicators: biological activity (carcinogens, mutagens, reprotoxicants class 1A and 1B in accordance with GHS, endocrine disruptors); stability in the environment; bioaccumulative potential; the possibility of cross-media transfer; aquatic toxicity (acute and chronic toxicity of hazard class 1 in accordance with GHS); production volumes (volumes of emissions and discharges); number of contacts. Conclusion. The analysis of the international practice of regulating highly hazardous chemicals indicates the need to implement at the national level and within the framework of the Eurasian Economic Union a program for the systematic monitoring of high-risk chemicals circulating on the market in order to withdraw them from circulation and replace them with safe analogues. Implementation of the concept of replacing highly hazardous substances with safe chemical alternatives allows to create a draft national list of banned and restricted highly hazardous chemicals relevant to various industries (food, materials, basic chemistry).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it