Clinical Significance of Circulating Clonal Plasma Cells Detected by a Novel Microfluidic Chip in Multiple Myeloma
Bibliographic record
Abstract
Circulating Clonal Plasma cells (cCPCs) in peripheral blood is emerged as an important biomarker in evaluating the Minimal Residual Disease (MRD) status in Multiple myeloma (MM). The elevation of cCPCs is closely related to the recurrence of disease. Comparing to the conventional bone marrow aspirate, it can be accessed regularly in a noninvasive manner. Over the past decade, microfluidic techniques have been widely explored as a platform to segregate the rare cells in blood with the advantages of easy manipulation and low cost. Recently, we and several other groups have reported the successful development of cCPCs-specific microfluidic chip. However, there had been no comparative study of the performance of microfluidic chip to currently available clinical MRD prognostic tools, so we used our previously developed microfluidic platform to explore its clinical utility in comparison with existing methods of Multiparameter Flow Cytometry (MFC) and Serum Protein Electrophoresis analysis. The MRD test results from the 19 MM patients showed 89.47% of overall agreement between MFC and microfluidic chip. Through the monitoring of 2 MM patients before and after treatment, a similar fluctuation pattern was observed between the cCPCs level detected by microfluidic chip and the paraprotein level detected by Serum Protein Electrophoresis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".