Reduction in work and activity impairment within 6 months of benralizumab initiation in Canadians with severe eosinophilic asthma
Bibliographic record
Abstract
<b>Background:</b> Nearly 8% of Canadian patients with asthma have severe disease, which is associated with significant impairment of work and daily activity. Benralizumab is an anti-IL-5Rα antibody for add-on maintenance therapy of severe eosinophilic asthma. <b>Objective:</b> To describe the change in work and activity impairment for patients with severe eosinophilic asthma within the first 6 months of benralizumab treatment. <b>Methods:</b> A prospective observational study (NCT03833141; POWER) was performed in 23 clinics across Canada from 2019 to current. Included patients had blood eosinophils ≥300c/µL, Asthma Control Questionnaire (ACQ-6) score ≥1.5, and were benralizumab naïve. Work and activity impairment was measured with the Work Productivity and Activity Impairment Questionnaire (WPAI), at baseline and 6 months. <b>Results:</b> Approximately 40% (n=56 of 102) and 35% (n=26 of 77) of patients reported employment at baseline and week 24, respectively. At baseline, impairment at work and daily activity ranged from 24% (absenteeism) to 65% (overall activities of daily life). Six months after treatment initiation, patient-reported impairment ranged from 2% (absenteeism) to 32% (overall activities); Figure 1. <b>Conclusion:</b> Throughout the first 6 months of treatment with benralizumab, patients reported a meaningful reduction of asthma-related impairment at work and during their activity of daily life.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".