Enhanced Proliferation and Growth of Human Stem Cells on the Surface of HVOF-Sprayed Nano TiO2-HA Coatings
Bibliographic record
Abstract
Abstract In this study, titania and hydroxyapatite nanopowder mixtures are deposited on medical grade titanium substrates by HVOF spraying. To assess bioperformance, human mesenchymal stem cells (hMSCs) were cultured from 1 to 21 days on the surface of HVOF-sprayed TiO2 and TiO2-HA samples. Plasma sprayed HA and uncoated Ti-6Al-4V substrates were used as controls. The active cultures were evaluated for cell proliferation, cytoskeleton organization, and cell-substrate interaction. The results for HVOF-sprayed TiO2-HA nanocomposite coatings show strong evidence of bone growth, proliferation, and attachment with cell-substrate interaction levels superior to those of air plasma sprayed HA coatings. Although there are no clear explanations for this favorable behavior, the topography and chemical composition of the surface of the coating appear to be playing important roles.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".