Circular RNA AEBP2 modulates dendritic cells by the hnRNP/pP65 signaling pathway
Bibliographic record
Abstract
Abstract Circular RNA (circRNA) has been the focus of research in recent years. However, circRNA is rarely reported in dendritic cells (DCs). In our study, Microarray analysis of circRNA showed that circular RNA AEBP2 (circAEBP2) is significantly up-regulated in mature DCs compared with immature DCs. Knockdown of circAEBP2 in DC with siRNA arrests DCs at immature status with lower expression of MHC class II, CD40, CD80, and CD83, as well as decreasing the expression of Phosphorylation of nuclear factor-kappa B p65. CircAEBP2 -silenced DCs failed to activate allogeneic CD4+ T cells and CD8+ T cells in vitro. RNA immunoprecipitation assays show heterogeneous nuclear ribonucleoproteins (hnRNP) are enriched by circAEBP2 probes which have complementary circAEBP2 sequence, indicating circAEBP2 interacts with hnRNP. The effect of circAEBP2 silenced DCs on induction of anti-tumor immunity is investigated in an ongoing murine melanoma model. In conclusion, our results demonstrate that circAEBP2 regulates the development and function of DCs through interacting the hnRNP/pP65 signaling pathway. CircAEBP2 will be a new potential target for DCs-based immunotherapy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".