Diffuse panbronchiolitis in a patient with humoral immunodeficiency successfully treated with erythromycin
Bibliographic record
Abstract
Abstract Diffuse panbronchiolitis (DPB) is a rare and under diagnosed disease of the respiratory tract that affects the lungs bilaterally in addition to the layers of the respiratory bronchioles. The condition commonly occurs in patients of Japanese ancestry. However, as international migration increases, more cases are arising in the United States. Clinicians rarely consider DPB in the differential when evaluating patients with lung disease as DPB mimics several other pulmonary disorders, especially in patients with humoral immunodeficiencies. We report the first case of DPB in a patient with humoral immunodeficiency that was successfully treated with erythromycin as evidenced by symptom control and follow-up. As our understanding of humoral immunodeficiencies improves, so must the recognition of rare pulmonary diseases such as DPB, which can mimic more common pulmonary disorders seen with humoral immunodeficiencies. Treatment for DPB involves macrolide antibiotics such as erythromycin for a minimum of 6 months duration. We have concluded that DPB can be successfully treated in humoral immunodeficiency with macrolides.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".