Gene expression profile of allergen-experienced group 2 innate lymphoid cells (HYP2P.323)
Bibliographic record
Abstract
Abstract We previously identified group 2 innate lymphoid cells (ILC2s) in mouse lungs. Upon allergen encounter, they produce type 2 cytokines and mediate T cell-independent allergic lung inflammation and also promote Th2 responses. We have recently found that allergen-treatments of mice result in significant increase in the number of ILC2s in the lung and lymph node even after the resolution of inflammation for several weeks. The allergen-experienced ILC2s are more responsive to unrelated allergens than naive ILC2s and rapidly induce allergic lung inflammation. To characterize the allergen-experienced ILC2s, we have performed microarray analysis of ILC2s purified from naïve mice and allergen-treated mice 4 days, 2 weeks, and 4 months after the treatment. The genes that are differentially expressed at different time points include those encoding chemokines, cytokines and their receptors, cell cycle and proliferation related proteins, adhesion molecules, and transcription factors. Gene Set Enrichment Analyses of the ILC2 populations revealed that allergen-experienced ILC2s are enriched for the gene signature of memory T cells. These results suggest that activated ILC2s undergo cell intrinsic changes and acquire memory-like features that are governed by the same set of genes as those responsible for memory T cell differentiation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".