Susceptibility of PIR-B deficient mice to Salmonella infection (101.1)
Bibliographic record
Abstract
Abstract Paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) isoforms are expressed by many blood cell types including B cells, dendritic cells, monocyte/macrophages, granulocytes, mast cells and megakaryocyte/platelets. To determine the role of PIR in infection, various doses of attenuated S. typhimurium (WB335) were inoculated i.v. into PIR-B−/− or wild-type mice. When given high doses of bacteria (>105 CFU), both types of mice died within 3 – 5 days post-infection. However, when given small doses (103– 104 CFU), all PIR-B−/− mice died within 1 – 3 weeks post-infection, whereas many control mice survived. The bacterial loads in liver, spleen and lung tissues during the 1st week of infection were much higher in PIR-B−/− mice than in control mice. PIR-B−/−, but not control, mice developed sepsis around day 7 post-infection. There were no significant differences in serum levels of cytokines (TNFα, IL1), liver enzymes (ALT, AST, ALK) and BUN or in splenic lymphoid and myeloid subsets between PIR-B−/− and control mice. Ingestion of bacteria by phagocytic cells ex vivo was also the same; however PIR-B−/− phagocytic cells exhibited tighter adherence to plates and released more nitrite than control phagocytic cells. These results suggest that PIR-B plays a role in regulating phagocytic cell responses against bacterial infection. (Supported by NIH/NIAID grant AI042127)
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".