Susceptibility of PIR-B deficient mice to Salmonella infection (101.1)
Bibliographic record
Abstract
Abstract Paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) isoforms are expressed by many blood cell types including B cells, dendritic cells, monocyte/macrophages, granulocytes, mast cells and megakaryocyte/platelets. To determine the role of PIR in infection, various doses of attenuated S. typhimurium (WB335) were inoculated i.v. into PIR-B−/− or wild-type mice. When given high doses of bacteria (>105 CFU), both types of mice died within 3 – 5 days post-infection. However, when given small doses (103– 104 CFU), all PIR-B−/− mice died within 1 – 3 weeks post-infection, whereas many control mice survived. The bacterial loads in liver, spleen and lung tissues during the 1st week of infection were much higher in PIR-B−/− mice than in control mice. PIR-B−/−, but not control, mice developed sepsis around day 7 post-infection. There were no significant differences in serum levels of cytokines (TNFα, IL1), liver enzymes (ALT, AST, ALK) and BUN or in splenic lymphoid and myeloid subsets between PIR-B−/− and control mice. Ingestion of bacteria by phagocytic cells ex vivo was also the same; however PIR-B−/− phagocytic cells exhibited tighter adherence to plates and released more nitrite than control phagocytic cells. These results suggest that PIR-B plays a role in regulating phagocytic cell responses against bacterial infection. (Supported by NIH/NIAID grant AI042127)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".