Simultaneous Estimation of Metoprolol and Telmisartan in Combined Tablet Dosage Form by Using RP-HPLC and UV Spectrophotometry
Why this work is in the frame
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Bibliographic record
Abstract
An accurate, precise and reproducible RP-HPLC and UV Spectrophotometric method was developed and validated for the simultaneous estimation of Metoprolol and Telmisartan in tablet dosage form. The chromatographic separation was carried out on X-tera C8 column (100mm*4.6mm*5µ), by using the mobile phase (0.05M Sodium phosphate buffer pH 2.8 and methanol) in the ratio 35:65, at a flow rate 1.2ml/min. The detection was carried out at a wave length of 226nm. The retention time for Metoprolol and Telmisartan was found to be 2.338 and 5.559 respectively. UV method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 223nm and 296nm λmax of Metoprolol and Telmisartan respectively. Beer’s law was obeyed in the concentration range of 1.25-6.25μg/ml and 2-10μg/ml for Metoprolol and Telmisartan respectively. The developed methods were validated according to ICH guidelines.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it