S870 Physical Activity as an Adjunct Therapy in Quiescent and Mildly Active Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Bibliographic record
Abstract
Introduction: Individuals with IBD in remission (i.e. quiescent IBD) can continue to have several symptoms, such as fatigue and depression. Physical activity (PA) may benefit people with quiescent IBD by improving immunological response and psychological health. The aim of our study was to distill available evidence on the efficacy and safety of PA to relieve persistent symptoms of fatigue, joint pain, abdominal pain, stress, anxiety, and depression; and improve health-related quality of life (HRQoL) in individuals with quiescent or mildly active IBD. Methods: We searched for RCTs and non-RCTs in eight databases, trial registries and conference proceedings. Trials using PA as an adjunct therapy in the management of adults ( >18 years) with quiescent or mildly active IBD, published in English between 2011 and 2021 were identified. Risk of bias of RCTs and non-RCTs was assessed using the Cochrane Risk of Bias tool and Newcastle Ottawa scale respectively. Results: We identified seven RCTs and one non-RCT that met our inclusion criteria. PA was moderately efficacious in improving HRQoL among trials using similar outcome measures (standardized mean difference (SMD) 0.51, 95% CI 0.22 to 0.79; I2 0%), and reducing anxiety (SMD -0.35, 95% CI -0.65 to -0.05; I2 0%). There was insufficient evidence to make conclusions regarding changes in fatigue and depression. Only one study reported on stress, and only one study reported on joint pain. None was identified for abdominal pain. All trials deemed PA safe for individuals with quiescent or mildly active IBD who experience persistent symptoms. Average adherence rate in PA programs was 69%. (Figure) Conclusion: PA is efficacious in improving HRQoL and alleviating anxiety in those with quiescent or mildly active IBD. However, more RCTs are required to precisely estimate the magnitude of effect and make more definitive conclusions about the efficacy of PA as an adjunct therapy for adults with IBD.Figure 1.: Sub-Group Analysis HRQoL
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.012 | 0.029 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.020 | 0.029 |
| Bibliometrics | 0.007 | 0.007 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".