Prenatal exposure to multiple persistent organic pollutants and adiposity markers and blood pressure in 12-year-old children
Bibliographic record
Abstract
Background. Several studies reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with greater adiposity in childhood. Few studies have assessed whether this finding persists into adolescence and have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in 12-year-old children. Methods. This study included 1658 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (Dichlorodiphenyldichloroethylene [DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed by biomarkers. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio>0.5), percentage of fat mass, and blood pressure were measured around 12 years old. Single-exposure associations were studied using linear and logistic regressions and the POP mixture effect was evaluated using Quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and were performed for boys and girls together and separately. Results. Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95% CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.80 [0.28; 1.32]) at 12 years old. These mixture effects were also statistically significant using BKMR, and after stratification by sex. In overall, these associations were mainly driven by exposure to HCB and, to a lower extent, to β-HCH. Additionally, the single-exposure models showed an association between β-HCH and DDE with higher systolic blood pressure, especially in girls (beta [95% CI] of DDE for girls = 0.91 [0.06; 1.76], p sex-interaction=0.08). Conclusion. This study suggests that prenatal exposure to POPs, especially to organochlorine pesticides, remains associated with adiposity markers until age 12. Keywords. Chemicals; Body mass index; Mixture; Birth cohort
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".