Screening for signs of portal hypertension by esophagogastroduodenoscopy in patients with <i>BCR‐ABL</i> negative myeloproliferative neoplasms
Bibliographic record
Abstract
To the Editor: Non-cirrhotic portal hypertension (PH) is a well-recognized yet poorly characterized complication of BCR-ABL negative myeloproliferative neoplasms (MPN).Diagnosis is often delayed until decompensation occurs.Screening for gastroesophageal varices (GEVs), one of the most clinically significant manifestations of PH, is not routinely performed in MPN patients but might facilitate early diagnosis and intervention.Portal vein thrombosis (PVT) is a known cause of PH in MPN.PVT can remain asymptomatic and undetected until overt PH manifests.Indeed, GEVs are highly prevalent in patients with chronic PVT. 1 PH can also occur in the absence of splanchnic circulation thrombosis, with portosinusoidal vascular disease (PSVD), sinusoidal obstruction due to extramedullary hematopoiesis (EMH), and increased portal blood flow due to splenomegaly as proposed mechanisms. 2 How PH should be evaluated in MPN patients is unknown.Doppler ultrasonography (USG) can detect asymptomatic PVT, identifying patients who may benefit from anticoagulation.Analogously to liver cirrhosis, the early detection of GEV by esophagogastroduodenoscopy (EGD) may facilitate interventions to prevent variceal hemorrhage.However, there is a lack of epidemiological data on asymptomatic PVT and GEV in MPN patients to guide such screening.A study from
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.018 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.006 | 0.006 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".