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Record W4318168174 · doi:10.1128/aac.01331-22

N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle

2023· article· en· W4318168174 on OpenAlexafffund
Aïssatou Aïcha Sow, Felix Pahmeier, Yann Ayotte, Anaïs Anton, Clément Mazeaud, Tania Charpentier, Léna Angelo, Simon Woo, Berati Cerikan, Darryl Falzarano, Levon Abrahamyan, Alain Lamarre, Patrick Labonté, Mirko Cortese, Ralf Bartenschlager, Steven R. LaPlante, Laurent Chatel‐Chaix

Bibliographic record

VenueAntimicrobial Agents and Chemotherapy · 2023
Typearticle
Languageen
FieldMedicine
TopicMosquito-borne diseases and control
Canadian institutionsUniversité du QuébecUniversité de MontréalUniversity of SaskatchewanInstitut National de la Recherche Scientifique
FundersCanadian Institutes of Health ResearchFonds de Recherche du Québec - SantéAnimal and Plant Health AgencyMitacsQuébec Consortium for Drug DiscoveryInnovation SaskatchewanGovernment of CanadaInstitut national de la recherche scientifiqueDeutsche ForschungsgemeinschaftUniversity of AlbertaArmand-Frappier FoundationDeutsches Zentrum für InfektionsforschungCourtois FoundationAix-Marseille Université
KeywordsDengue virusVirologyRepliconBiologyDengue feverFlavivirusViral replicationAntiviral drugRNASubgenomic mRNAVirusDNAGeneGeneticsPlasmid

Abstract

fetched live from OpenAlex

Dengue virus (DENV) is a Flavivirus that causes the most prevalent arthropod-borne viral disease. Clinical manifestation of DENV infection ranges from asymptomatic to severe symptoms that can lead to death.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.259
Teacher spread0.247 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2023
Admission routes2
Has abstractyes

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