Prospective-Controlled Assessment of Stress Hormones and Pain In Patients Undergoing Myomectomy as Performed by Laparoscopy Against Laparotomy
Bibliographic record
Abstract
Introduction:In this prospective study we assessed the surgical stress and post-operative pain through the determination of stress hormones and patient discomfort, as well as the comparison of the stress hormones' response after myomectomy performed by laparoscopy versus laparotomy Methods: In this prospective matched case control study (Canadian Task Force classification II-2), which was performed in the Gynecological Department of University Hospital and Centre for Gynecological Endoscopy Private Hospital, sixty women with symptomatic growth of known uterine leiomyomas or leiomyomas compromising the shape of the uterus, were operated.Thirty women underwent laparoscopic myomectomy and thirty removal of leiomyomas through laparotomy.Three venous samples were received from each patient for determination of stress hormones (one before surgery, the second at the end of the surgical procedure and the third on the morning of the first postoperative day) and a questionnaire was administered the first post-operative day, in which the patients indicated the level of pain through a Visual Analog Scale of Pain (VASP).The main outcome measures were assessment of stress hormones and patient discomfort between the two groups on the first post-operative day.Results: Adrenocorticotropic Hormone (ACTH) and noradrenalin were significantly lower in the laparoscopy group on the first post-operative day (12.68±9.97pg/ml vs 15.90±9.02pg/ml p<0.025) and 20.7±7.28 ng/ml vs 22.33±5.82ng/ml, (p<0.027)respectively.No statistical difference was observed in cortisol levels on the first post-operative day (11.71±5.82μg/dl vs 11.81±7.61μg/dl, p>0.94).and, also, for b-endorphin levels (4.88±1.57vs 4.91± ng/ml, p>0.61).Postoperative pain was significantly lower in the laparoscopy group on the V.A.S.P scale (3.3±1.05vs 5.67±1.15respectively, p<0.001).Conclusions: laparoscopy is superior to laparotomy for the surgical removal of leiomyomas in terms of postoperative pain and surgical stress.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".