POSTER ABSTRACTS
Post-publication record
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Bibliographic record
Abstract
Introduction: Combined deficiency of coagulation factors V and VIII (F5F8D) is a constitutional bleeding disorder, described since 1954 by Oeri.It is rare, autosomal recessive, with an estimated prevalence of 1/100,000 to 1/1,000,000, representing the most frequent form of constitutional abnormality, associating more than one coagulation factor, and not related to the accidental coincidence of several genetically distinct inherited deficiencies, but related to a single genetic abnormality.Methods: A 56-year-old woman consulted an outpatient clinic with a complaint of continuous bleeding after tooth extraction.The patient's medical history revealed that she had been experiencing long-term bleeding episodes following a minor trauma, as well as easy bruising, ecchymoses, and menorrhagia following menstruation.Melena, hematochezia, hemoptysis, and hemarthrosis were not present in her case.Her parents were unrelated, and her vital signs and physical examination results were normal.Results: The coagulation profile revealed prolonged activated partial thromboplastin time and prothrombin time (17-20 sec and 45-66 sec, respectively).aPTT and PT values were normal after mixing the patient's plasma with a healthy plasma in a 1:1 ratio.Fibrinogen, factor VII, factor IX, factor X, and factor XI and von Willebrand factor levels were all normal.Factor V and VIII levels were measured twice, and both measured levels were low (respectively 10% and 15%).According to these findings, the patient was diagnosed as having a combined factor V and VIII deficiency.Discussion/Conclusion: Regular prophylaxisis not required during bleeding episodes in patients with combined factor V and VIII insufficiency, and the patient is often treated only as necessary.The treatment of the bleeding is replacement of factor V and VIII.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.004 | 0.001 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.677 | 0.403 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".