Network topologies for maximal organismal health span and lifespan
Bibliographic record
Abstract
The population dynamics of human health and mortality can be jointly captured by complex network models using scale-free network topology. To validate and understand the choice of scale-free networks, we investigate which network topologies maximize either lifespan or health span. Using the Generic Network Model (GNM) of organismal aging, we find that both health span and lifespan are maximized with a "star" motif. Furthermore, these optimized topologies exhibit maximal lifespans that are not far above the maximal observed human lifespan. To approximate the complexity requirements of the underlying physiological function, we then constrain network entropies. Using non-parametric stochastic optimization of network structure, we find that disassortative scale-free networks exhibit the best of both lifespan and health span. Parametric optimization of scale-free networks behaves similarly. We further find that higher maximum connectivity and lower minimum connectivity networks enhance both maximal lifespans and health spans by allowing for more disassortative networks. Our results validate the scale-free network assumption of the GNM and indicate the importance of disassortativity in preserving health and longevity in the face of damage propagation during aging. Our results highlight the advantages provided by disassortative scale-free networks in biological organisms and subsystems.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".