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Record W4322722649 · doi:10.54846/jshap/1313

Maximizing value and minimizing waste in clinical trial research in swine: Design features to minimize bias

2023· article· en· W4322722649 on OpenAlexafffund
Jan M. Sargeant, Annette M. O’Connor, Terri L. O’Sullivan, Alejandro Ramirez

Bibliographic record

VenueJournal of Swine Health and Production · 2023
Typearticle
Languageen
FieldMathematics
TopicStatistical Methods in Clinical Trials
Canadian institutionsUniversity of Guelph
FundersUniversity of Guelph
KeywordsBlindingProtocol (science)Clinical study designMedicineComputer scienceOutcome (game theory)Research designClinical trialPreferenceA priori and a posterioriStatisticsPlaceboMathematicsAlternative medicineInternal medicinePathology

Abstract

fetched live from OpenAlex

Researchers designing trials should implement design features intended to reduce bias. These include random allocation to intervention groups and blinding of caregivers and outcome assessors. The method of generating the random sequence should be reported, as well as methods for stratification or blocking if used. When blinding is not possible, objectively measured outcomes should be used. Allocation concealment may not be essential when all eligible pens or animals are enrolled and there is no preference for intervention group. An a priori trial protocol should be made publicly available, and results for all outcomes evaluated should be reported.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.685
metaresearch head score (Gemma)0.726
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.315
Threshold uncertainty score0.389

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.6850.726
Meta-epidemiology (narrow)0.0050.004
Meta-epidemiology (broad)0.0100.009
Bibliometrics0.0080.008
Science and technology studies0.0020.008
Scholarly communication0.0070.008
Open science0.0040.006
Research integrity0.0120.007
Insufficient payload (model declined to judge)0.0060.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.903
GPT teacher head0.682
Teacher spread0.221 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2023
Admission routes2
Has abstractyes

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