O-182 The association between the incidence of postmenopausal breast cancer and occupational exposure to selected organic solvents in Montréal
Bibliographic record
Abstract
Introduction Breast cancer is the most diagnosed cancer among women and accepted risk factors only explain 25% to 47% of cases. Organic solvents are used widely in the workplace. According to a hypothesis postulated in the 1990s, exposure to organic solvents may increase the risk of developing breast cancer, yet there is insufficient data to confirm this hypothesis. We sought to determine whether past occupational exposures to organic solvents reported to exert mammary toxicity were associated with the incidence of invasive breast cancer in postmenopausal women in Montréal. Materials and Methods From a population-based case-control study (2008 to 2011), using in-depth interviews, we elicited information on risk factors and lifetime occupational histories. A team of industrial hygienists and chemists translated each detailed job description into specific chemical and physical exposures. We selected six individual solvents and four solvent groups. Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) between indices of past exposures to the selected solvents and the risk of developing postmenopausal breast cancer. Indices of exposure included any previous exposure, frequency in hours per week, duration in years, and average cumulative concentration with concentration on a scale of 1 (‘low’), 2 (‘medium’), 3 (‘high’) weighted by hours per week exposed. Results We enrolled 695 cases and 608 controls. We found increased ORs for average cumulative concentration of exposure to monoaromatic hydrocarbons (OR:1.52, 95%CI: 1.04, 2.28), chlorinated alkanes (OR: 2.42, 95%CI: 1.23, 5.68), toluene (OR: 1.59, 95%CI: 1.02, 2.59), and the group of organic solvents with reactive metabolites (OR: 1.53, 95%CI: 1.08, 2.24). Positive associations were found across all metrics of exposure and were higher among women who had estrogen positive/progesterone negative tumours. Conclusion Our findings suggest that occupational exposure to certain organic solvents may increase the risk of incident postmenopausal breast cancer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".