O-182 The association between the incidence of postmenopausal breast cancer and occupational exposure to selected organic solvents in Montréal
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
<h3>Introduction</h3> Breast cancer is the most diagnosed cancer among women and accepted risk factors only explain 25% to 47% of cases. Organic solvents are used widely in the workplace. According to a hypothesis postulated in the 1990s, exposure to organic solvents may increase the risk of developing breast cancer, yet there is insufficient data to confirm this hypothesis. We sought to determine whether past occupational exposures to organic solvents reported to exert mammary toxicity were associated with the incidence of invasive breast cancer in postmenopausal women in Montréal. <h3>Materials and Methods</h3> From a population-based case-control study (2008 to 2011), using in-depth interviews, we elicited information on risk factors and lifetime occupational histories. A team of industrial hygienists and chemists translated each detailed job description into specific chemical and physical exposures. We selected six individual solvents and four solvent groups. Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) between indices of past exposures to the selected solvents and the risk of developing postmenopausal breast cancer. Indices of exposure included any previous exposure, frequency in hours per week, duration in years, and average cumulative concentration with concentration on a scale of 1 (‘low’), 2 (‘medium’), 3 (‘high’) weighted by hours per week exposed. <h3>Results</h3> We enrolled 695 cases and 608 controls. We found increased ORs for average cumulative concentration of exposure to monoaromatic hydrocarbons (OR:1.52, 95%CI: 1.04, 2.28), chlorinated alkanes (OR: 2.42, 95%CI: 1.23, 5.68), toluene (OR: 1.59, 95%CI: 1.02, 2.59), and the group of organic solvents with reactive metabolites (OR: 1.53, 95%CI: 1.08, 2.24). Positive associations were found across all metrics of exposure and were higher among women who had estrogen positive/progesterone negative tumours. <h3>Conclusion</h3> Our findings suggest that occupational exposure to certain organic solvents may increase the risk of incident postmenopausal breast cancer.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it