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Record W4327860477 · doi:10.1017/9781108917919.011

Case Studies of Platform Trials

2023· book-chapter· en· W4327860477 on OpenAlexaff
Jay Park, J. Kyle Wathen, Edward J. Mills

Bibliographic record

VenueCambridge University Press eBooks · 2023
Typebook-chapter
Languageen
FieldMathematics
TopicStatistical Methods in Clinical Trials
Canadian institutionsMcMaster University
Fundersnot available
KeywordsClinical trialComputer scienceCoronavirus disease 2019 (COVID-19)MedicineMedical physicsPathologyDisease

Abstract

fetched live from OpenAlex

In this chapter, we discuss four adaptive randomised platform trials as case studies. We review two of the longest ongoing platform trials and another two important examples of ongoing platform trials conducted for COVID-19.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.078
metaresearch head score (Gemma)0.183
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.922
Threshold uncertainty score0.413

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0780.183
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0030.005
Science and technology studies0.0030.007
Scholarly communication0.0070.006
Open science0.0040.006
Research integrity0.0080.006
Insufficient payload (model declined to judge)0.0160.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.779
GPT teacher head0.511
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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